Her personal life, particularly her relationship with Marilyn Manson, to whom she was previously engaged, has attracted press attention.Her father, Ira David Wood III, is a locally prominent actor, singer, theater director, playwright, and from a Christian family; he is the Executive Director of a local regional theatre company called Theatre in the Park.Wood and her brothers were actively involved in Theatre in the Park while growing up, including an appearance by her in the 1987 production of her father's musical comedy adaptation of A Christmas Carol when she was just a few months old.
The film showed at the San Francisco International Film Festival, where she received an award at the Midnight Awards along with Elijah Wood.
Wood continued acting mostly in independent films, including Pretty Persuasion (2005), Down in the Valley (2005), Running with Scissors (2006), and in the big studio production Across the Universe (2007).
Since 2008, Wood has appeared in more mainstream films, including The Wrestler (2008), Whatever Works (2009) and The Ides of March (2011).
During the time of Thirteen A supporting role opposite Cate Blanchett and Tommy Lee Jones in Ron Howard's The Missing, in which she played the kidnapped daughter, Lilly Gilkeson, followed the same year, as well as a role in the CSI: Crime Scene Investigation episode "Got Murder? In 2005, Wood appeared in the Mike Binder-directed The Upside of Anger, opposite Kevin Costner and Joan Allen, a well-reviewed film in which Wood played Lavender "Popeye" Wolfmeyer, one of four sisters dealing with their father's absence. Wood's next two starring roles were in dark independent films.
In the 2005 Grand Jury Prize Sundance Film Festival nominee Pretty Persuasion, a black comedy/satirical focusing on themes of sexual harassment and discrimination in schools and attitudes about females in media and society, Wood played Kimberly Joyce, a manipulative, sexually active high-schooler.